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Courteney Cox and David Arquette's breakup may have come as a shock to some, but with the recent breakup of Cox's best friend Laura Dern and Ben Harper's marriage, we can't help but wonder if that created some sort of domino effect for the couple.

Harper said that he and Dern, who were together for about ten years, but married for only five, have been separated since January. And Courteney and David have also been separated for some time now, they confirmed in a statement.

When couples are as close as the Arquettes and the Harpers, are problems in one marriage are bound to affect the other?

Both couples have been together for over a decade (Courteney and David for about 15 years) and married about five years after dating -- the Arquettes in 1999 and Dern and Harper in 2005.

Their children are similarly close in age. Laura and Ben's eldest, Ellery, is nine, and their daughter Jaya is 5. Coco Arquette is 6.

Over the years, Courteney and David were often seen in the company of Laura and Ben sharing birthday parties together, beach get-togethers in Malibu, and even family vacations. Coco Arquette spent so much time with Laura's two kids Ellery and Jaya, she apparently even developed a crush on Ellery!

But now, it seems the ladies are set to join the divorcees club with another one of their famous pals, Jennifer Aniston.

As close as those three are (along with Sheryl Crow) we bet they'll have plenty of support. And just think of the wild girl's nights out in their futures!