David Arquette has been busy promoting his latest project Scream 4, but while on KIIS-FM with Ryan Seacrest this morning, the 39-year-old actor addressed the rumors his estranged wife Courteney Cox has been hooking up with her co-star Josh Hopkins.

Arquette tells Seacrest:

    "She went away to St. Barth's with Coco and her best friend and Josh from the show, and I knew about all this. But the tabloids make it like there's some kind of scandal going on. There's no scandal, we're really honest and open, we care about each other."

David adds, "We definitely are friendly. She's my best friend, our relationship right now is better than ever. We're not together. We're still separated."

The couple announced their split last October after 15 years of marriage. Find out what Cox's rep said about her relationship with Hopkins ... after the jump.