HandlerTHRCover.jpgChelsea Handler may be putting an end to her super-successful E! talk show, she tells The Hollywood Reporter.

In the latest issue's cover story, Handler tells the mag:

    "I want to do something that's going to utilize my brain a little more than this show. ... my brain is bleeding. I want to do something that's more mindful and isn't celebrity-centered."

The comedienne has built an empire based on best-selling books and her hit TV show, which premiered on E! in 2007. Her contract with the cable network expires at the end of 2012 and Handler is currently in negotiations for a new deal. She says:

    "We'll see how it goes and if it works out for me to stick around here. It's a lengthy process. They tell you you're valuable, and then you get a counter and you think, 'I guess you really don't care about me at all.' Nothing is set in stone, so if things go south, then obviously I'll be moving along."

Chelsea Lately brought in $40 million in ad revenue for E! in 2009, so the network certainly sees some value in Handler right now. The show gets about 1 million viewers, coming in fourth on E! behind the Kardashians' shows, Kendra and Holly's World.

But Handler, who is now worth about $22 million on her own, thanks to her four books, Lately, Are You There, Vodka? (her new pilot on NBC, E!'s sister network) and stand-up tours, may not need E! anymore. Even if the she stays at E!, Handler guarantees her show will change. See how after the jump.