We already saw pictures from the set of Dallas Buyers Club showing Matthew McConaughey's dramatic weight loss and Jared Leto in drag, and now the film's first trailer has finally hit the web.

McConaughey plays Ron Woodruff, a Texas cowboy who is diagnosed with HIV in the 1980s, and it follows his mission to import unapproved drugs to help provide treatment to fellow HIV-positive patients. Leto plays a transsexual who ends up becoming Woodruff's close pal and business partner, and Jennifer Garner stars as Woodruff's doctor Eve Saks.

Dallas Buyers Club hits theaters on December 6, but it's already generates some early Oscar buzz, specifically over Leto's performance ... check out the clip above!