Johnny Depp is keeping it all in the family!

The Oscar winner is set will to co-star with his 15-year-old daughter Lily-Rose in the upcoming Kevin Smith film Yoga Hosers, People reports. The comedy-action movie, which features Justin Long, Adam Brody, Tyler Posey and Natasha Lyonne, will be quite the family affair -- in addition to Depp's offspring, Smith's 15-year-old daughter Harley Quinn nabbed the other lead role.

In the film, Lily-Rose and Harley Quinn play bored, yoga-loving convenience store clerks who most go against manhunter Guy Lapointe (played by Depp).

Smith has said he is often asked whether or not he will make a comic book movie -- and this film is his answer to that -- honoring his love of comic books and the strength of teenage girls.

"This is it – but instead of yet another dude saving the day, our antiheroes are the most feared and formidable creatures man has ever encountered: two 15-year-old girls."

The movie, which begins filming this week, is the second installment in Smith's True North Trilogy -- and is the follow-up to Tusk.