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Suge Knight is in trouble again ... this time for leaving the scene of a hit-and-run that left a victim dead on the streets of Compton.

Knight got into a fight on the set of a film project involving Ice Cube and Dr. Dre, according to TMZ. He left to go to a fast-food restaurant and the other rappers weren't around when Suge and two other men got into it again, leading Suge to gun his big red truck in reverse and run over the victim TWICE before leaving the scene, according to the web site.

The Sheriff's Department has issued a bulletin to all Southern California police to be on the lookout for Knight.

UPDATE - Suge has turned himself in, cops formally arrested him on murder charges and bail has been set at $2 million.