Rob Lowe looks like he's interested in being Kelly Ripa's Live! co-host and it looks like the feeling is mutual! ET is reporting that ABC is seriously looking at Lowe to be Kelly's new co-host.

The network has apparently been talking to Lowe's reps, a source tells the site. This isn't the first time Lowe's been in the running to host the show, back in 2012, the network was looking at him to become Regis Philbin's replacement.

Apparently, the 52-year-old impressed the viewers during his two-day stint, but execs gave the highly coveted position to Michael Strahan.

Lowe's schedule just cleared up after his FOX show, The Grinder, got canceled earlier this month.

On Monday, ET visited Lowe on the set of his upcoming film, How to Be a Latin Lover, and the hunky perfect-faced actor said he was definitely down for the potential new gig.

The actor said, "I hosted it with Kelly and had the time of my life. I love her ... I love being able to talk to an audience every morning like that and just being fun, counter-punching, being silly, and talking about cool stuff."

Lowe also said that the timing is right -- his 19-year-old son, John, is currently attending Stanford University, and his elder son, 21-year-old Matthew, is headed to law school.

"My kids are out of the house, they weren't then. Who knows... But listen, man, I don't want to go up against Anderson Cooper," he joked. "I don't know if I'm going to go back as an actual guest host yet. ... You never know! You never know."

Cooper is believed to be frontrunner for the hosting gib, but the CNN man has said he hasn't been "offered anything."

The Anderson Cooper 360 host said on Bravo's Watch What Happens Live!"Look, I'm very happy at CNN. It would be a dream to work with Kelly, but nobody's offering anything."

He added, "Listen, I love Kelly and I think Kelly is the heart and soul of that show, and it's gonna go on and continue to be great."

We're voting for Rob!