What a difficult time for the family.

Following Alexis Arquette's sudden passing at age 47 on Sunday, her brother David and his ex Courteney Cox are breaking their silence on the tragic loss. X17online was the first to break the story.

"Thank you all for your love and kind words about Alexis. My hero for eternity," the Scream actor tweeted. "My heart goes out to anyone who was lucky enough to know Alexis. We will love and miss you forever," the Friends star wrote in her own statement.

Eldest brother Richmond Arquette confirmed the sad news in a touching Facebook post yesterday.

"Our brother Robert, who became our brother Alexis, who became our sister Alexis, who became our brother Alexis, passed this morning September 11, at 12:32 am. He was surrounded by all of his brothers and sisters, one of his nieces and several other loved ones. We were playing music for him and he passed during David Bowie's 'Starman.' As per his wishes, we cheered at the moment that he transitioned to another dimension," he wrote.

Arquette was said to be suffering from an unknown illness, but an official cause of death has yet to be released. RIP.