There must be something in the water!

Jennifer Aniston and Chelsea Handler and Drew Barrymore and Cameron Diaz are two of Hollywood's most notorious bestie pairs, but it sounds like their friendships are a thing of the past.

Let's start with the A-list actress and the Chelsea Lately host's falling out. Apparently, they had a nasty blowout fight and they're no longer friends - pun intended!

"Jennifer found out that Chelsea was spilling secrets about her marriage, and talking behind her back. Everyone is surprised over this because they were such close friends, but Jen knew that it had to be someone really close to her that was talking — and found out it was Chelsea!” a source dished to Radar.

The Cake star then ordered her longtime publicist Stephen Huvane to cut ties with the comedienne.

"Stephen dumped Chelsea after she had a huge blow-up with Jennifer, who is one of his very top-priority clients. He’s no longer representing Chelsea,” the source added.

As far as Drew Barrymore and Cameron Diaz go, things aren't quite as dramatic. The former wild child just isn't the biggest fan of Cammy's husband Benji Madden, and it's put some distance between them.

"Drew is no fan of Benji, and it’s a big reason for her and Cameron’s once-close friendship fading. The truth is Drew can’t stand him. As far as Drew’s concerned, Cameron’s changed and not for the better," another source told the outlet.

"Benji reminds her of all the bad boys she used to hang out with and get into major trouble when she was a teen. She worries he’s bad for Cameron. She’s definitely lost her bubbly spark since marrying him," the source revealed.

Sounds like it's time for all of them to find some new gal pals!